Andrew Sheridan will return to the England side for Saturday's final World Cup warm-up match against Ireland.
The 31-year-old missed the opening two warm-ups after summer shoulder surgery.
England will test a new centre pairing of Mike Tindall and Manu Tuilagi, while Chris Ashton returns on the wing and flanker James Haskell is fit to start.
Jonny Wilkinson and Richard Wigglesworth form a new half-back combination and scrum-half Joe Simpson could make his debut off the bench.
The team features six changes from the 19-9 defeat by Wales in Cardiff and provides the strongest indication yet of manager Martin Johnson's first choice World Cup side.
Steve Thompson gets the nod over Dylan Hartley to continue at hooker alongside Sheridan and Dan Cole, while Louis Deacon and Courtney Lawes are paired together at lock with Tom Palmer not even in the 22, Simon Shaw on the bench.
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